For the current directory and subdirectories...
du | sort -gFor the entire drive (will likely take a while and must either sudo or perform as root)...
du / | sort -g | tailWhich users are keeping the most in their home directories (again, sudo or root)...
du /home --max-depth=1 | sort -gFor Windows users, the graphical tool WinDirStat is available.
For Android users, there's DiskUsage. (Also available in the Google App Market, but I refuse to put market:// links until the App Market is available for general use.)